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產(chǎn)品英文名稱: IWP-2
產(chǎn)品中文名稱: IWP-2

IWP-2 產(chǎn)品英文簡述:
IWP-2:N-（6-Methyl-2-benzothiazolyl）-2-[（3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl）thio]-acetamide, is a specific inhibitor of the O-acyltransferase Porcupine with IC50=27nM （Ref.）. Inhibition blocks the production of Wnt proteins that require fatty acid modifications, thus disrupting Wnt-dependent signaling. Porcupine inhibitor represent a novel class of potential therapeutics for cancer and other WNT dependent diseases.

Ref: B. Chen, et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5, 100 （2009）
 

Purity: Greater than 99.5% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.
Biological Activity: In a cell-based assay measuring the activation of the TCF reporter gene, this compound gives IC50 of 30 nM.

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